Abstract

Pulmonary aspiration is a potentially lethal perioperative complication related to gastric size and contents. Several perioperative factors are believed to increase gastric size, while others are less studied. This prospective observational study aimed to investigate the effect of preoperative anxiety and hormone-induced ovarian stimulation on gastric size examined by gastric ultrasound. We recruited 49 female patients undergoing hormone-induced ovarian stimulation and oocyte retrieval for in vitro fertilization at Rabin Medical Centre, Petah Tikva, Israel. Preoperatively, women ranked their anxiety level using a verbal numeric anxiety score (VNS). In addition, we recorded the extent of ovarian stimulation and measured the antral cross-sectional area (CSA) using gastric ultrasound. There was no substantial correlation between preoperative VNS anxiety and antral CSA (p = .697). Moreover, the number of follicles, blood estradiol, and progesterone levels did not correlate with antral CSA (p = .590, p = .104, and p = .511, respectively). In conclusion, neither preoperative anxiety nor extensive ovarian stimulation affects gastric size in fasting healthy patients. However, further studies are warranted in this area to define these findings better. Trial registration: Clinicaltrials.gov, identifier: NCT04833530

摘要

肺误吸是一种潜在致命的围手术期并发症，与胃的大小和内容物有关。一些围手术期因素被认为会增加胃的大小，而其他因素研究较少。这项前瞻性观察性研究旨在探讨术前焦虑和激素诱导的卵巢刺激对胃超声检查胃大小的影响。我们在以色列佩塔提克瓦的拉宾医疗中心招募了 49 名接受激素诱导卵巢刺激和取卵进行体外受精的女性患者。术前，女性使用口头数字焦虑评分 (VNS) 对她们的焦虑程度进行排名。此外，我们记录了卵巢刺激的程度，并使用胃超声测量了胃窦横截面积 (CSA)。术前 VNS 焦虑与胃窦 CSA 之间没有显着相关性 (p = .697)。此外，卵泡数量、血液雌二醇和孕酮水平与胃窦 CSA 无关（分别为 p = .590、p = .104 和 p = .511）。总之，术前焦虑和广泛的卵巢刺激都不会影响禁食健康患者的胃大小。然而，在这一领域需要进一步研究以更好地定义这些发现。试验注册：Clinicaltrials.gov，标识符：NCT04833530 需要在该领域进行进一步研究以更好地定义这些发现。试验注册：Clinicaltrials.gov，标识符：NCT04833530 需要在该领域进行进一步研究以更好地定义这些发现。试验注册：Clinicaltrials.gov，标识符：NCT04833530