Loss-of-function variants of TREM2 increase risk for Alzheimer’s disease. A new study presents a therapeutic candidate — ATV:TREM2, a TREM2-activating antibody engineered with a transferrin receptor binding site to facilitate blood-to-brain transport. Treatment of a mouse model of Alzheimer’s disease with ATV:TREM2 improved energy metabolism and microglial function.

中文翻译：

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TREM2 抗体为小胶质细胞提供能量


TREM2 的功能丧失变异会增加患阿尔茨海默病的风险。一项新的研究提出了一种候选治疗药物——ATV:TREM2，这是一种 TREM2 激活抗体，经过改造，带有转铁蛋白受体结合位点，可促进血液到大脑的转运。用 ATV:TREM2 治疗阿尔茨海默病小鼠模型可改善能量代谢和小胶质细胞功能。