The management of the interface between the wound microenvironment and the skin substitute (SSS) is fundamental to wound repair and is an important factor in the regeneration of damaged tissue. Current biomaterials result in unideal repair effect of defective tissue due to limited management of early wound exudate and inability to respond positively to endogenous growth factors. Based on a refined electrospinning process, polycaprolactone fiber - alginate hydrogel interpenetrated network scaffold and subsequent multifunctional modifications serving as SSS was developed. The SSS exhibits excellent water absorption, water vapor permeability rate > 6000 g/m²/day and stretching properties. The amino-terminated hyperbranched polyamide enables the scaffold with both rapid antibacterial and reactive oxygen scavenging properties. Furthermore, fibroblast cells can be proliferated in the scaffold by 3D infiltration (>100 μm). Thus, the scaffolds are expected to be ideal candidates for the repair of different defective skin, especially those with excessive exudate.

伤口微环境与皮肤替代物 (SSS) 之间界面的管理是伤口修复的基础，也是受损组织再生的重要因素。目前的生物材料由于对早期伤口渗出物的管理有限以及无法对内源性生长因子做出积极反应，导致缺陷组织的修复效果不理想。基于精细的静电纺丝工艺，开发了聚己内酯纤维-海藻酸盐水凝胶互穿网络支架和作为 SSS 的后续多功能修饰。SSS表现出优异的吸水性，透湿率> 6000 g/m ²/天和拉伸性能。氨基封端的超支化聚酰胺使支架具有快速抗菌和活性氧清除特性。此外，成纤维细胞可以通过 3D 浸润 (>100 μm) 在支架中增殖。因此，支架有望成为修复不同缺陷皮肤的理想选择，尤其是渗出过多的皮肤。