Sila-isosteres have attracted increasing attention due to their potential application in a variety of fields and their different properties compared to their carbon-containing analogs. However, the preparation of these silicon-containing compound remains challenging and thus the development of alternative synthetic methodologies is desirable. Here, we employ B(C₆F₅)₃ as catalyst to enable the synthesis of highly functionalized sila-benzoazoles via hydrosilylation and rearrangement cascade reaction of benzoazoles and commercially available silanes. This strategy also exhibits remarkable features such as 100% atom-economy, good functional group tolerance, broad substrate scope, easy scale-up and good catalytic performance, demonstrating its potential application in sila-isostere synthesis.

Sila-等排体由于其在各个领域的潜在应用以及与含碳类似物相比的不同特性而引起了越来越多的关注。然而，这些含硅化合物的制备仍然具有挑战性，因此需要开发替代的合成方法。在这里，我们使用B(C ₆ F ₅ ) ₃作为催化剂，通过苯并唑和市售硅烷的氢化硅烷化和重排级联反应合成高功能化的硅苯并唑。该策略还表现出100%原子经济性、良好的官能团耐受性、广泛的底物范围、易于放大和良好的催化性能等显着特点，展示了其在硅等排体合成中的潜在应用。