当前位置：
X-MOL 学术
›
Angew. Chem. Int. Ed.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Catalytic Asymmetric Synthesis of Axially Chiral Diaryl Ethers through Enantioselective Desymmetrization
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-02-09 , DOI: 10.1002/anie.202300481 Hanyang Bao 1 , Yunrong Chen 1 , Xiaoyu Yang 1
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-02-09 , DOI: 10.1002/anie.202300481 Hanyang Bao 1 , Yunrong Chen 1 , Xiaoyu Yang 1
Affiliation
|
A highly efficient enantioselective desymmetrization protocol is disclosed for the asymmetric synthesis of axially chiral diaryl ethers by using a chiral phosphoric acid-catalyzed electrophilic aromatic amination. This method features broad substrate scope, high yields and high enantioselectivity. The facile derivatization of various products into a series of structurally novel azaarene-containing diaryl ether atropisomers was also demonstrated.
中文翻译：
对映选择性去对称催化不对称合成轴手性二芳基醚
公开了一种高效的对映选择性去对称化协议，用于通过使用手性磷酸催化的亲电芳香胺化来不对称合成轴向手性二芳基醚。该方法底物适用范围广、产率高、对映选择性高。还证明了将各种产品轻松衍生成一系列结构新颖的含氮杂芳烃的二芳基醚阻转异构体。
更新日期：2023-02-09
中文翻译：
对映选择性去对称催化不对称合成轴手性二芳基醚
公开了一种高效的对映选择性去对称化协议，用于通过使用手性磷酸催化的亲电芳香胺化来不对称合成轴向手性二芳基醚。该方法底物适用范围广、产率高、对映选择性高。还证明了将各种产品轻松衍生成一系列结构新颖的含氮杂芳烃的二芳基醚阻转异构体。
京公网安备 11010802027423号