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Ligand-Promoted Rosenmund–von Braun Reaction
Synlett ( IF 1.7 ) Pub Date : 2023-02-09 , DOI: 10.1055/s-0042-1751414 Dawei Ma 1, 2 , Quan Zhang 2
中文翻译：
配体促进的罗森蒙德-冯布劳恩反应
更新日期：2023-02-10
Synlett ( IF 1.7 ) Pub Date : 2023-02-09 , DOI: 10.1055/s-0042-1751414 Dawei Ma 1, 2 , Quan Zhang 2
Affiliation
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Two picolinamide ligands were found to have significant accelerating effect to classical Rosenmund–von Braun reaction, making the coupling of (hetero)aryl bromides with CuCN occur at 100–120 °C with good to excellent yields in most cases. A large number of functional groups and heterocycles were tolerated under these conditions, thereby providing a convenient and reliable approach for diverse synthesis of aryl nitriles.
中文翻译：
配体促进的罗森蒙德-冯布劳恩反应
发现两种吡啶甲酰胺配体对经典的 Rosenmund-von Braun 反应具有显着的加速作用，使得（杂）芳基溴化物与 CuCN 的偶联发生在 100-120 °C，在大多数情况下具有良好至优异的产率。在这些条件下可以容忍大量的官能团和杂环，从而为芳基腈的多样化合成提供了一种方便可靠的方法。
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