The degradation of some common NSAIDs containing an arylacetic acid moiety via thermal oxidative decarboxylation using potassium persulfate (K2S2O8) in water at 80 °C has been investigated. A neutral pH condition is critical for efficient degradation of the drugs yielding the degraded products (corresponding carbonyl compounds). The drugs remain unaffected at lower (2-3) or higher pH (9-10). Unlike the common practice of identification of pharmaceutical degradation products by LC-MS data, the current report unveils major degradation products through isolation and identification using standard analytical techniques. The mechanism of the formation of degradation products via a radical pathway is discussed. The current report on NSAIDs degradation features a rare study in the contemporary pharmaceutical degradation dispersed in the literature.

中文翻译：

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硫酸根阴离子 (SO

使用过硫酸钾 (K 2 S 2 O 8) 在 80 °C 的水中进行了研究。中性 pH 条件对于产生降解产物（相应的羰基化合物）的药物的有效降解至关重要。药物在较低 (2-3) 或较高 pH (9-10) 下不受影响。与通过 LC-MS 数据鉴定药物降解产物的常见做法不同，本报告使用标准分析技术通过分离和鉴定揭示了主要的降解产物。讨论了通过自由基途径形成降解产物的机制。目前关于 NSAIDs 降解的报告具有罕见的当代药物降解研究分散在文献中。