The accumulation of bilirubin in blood is associated with many diseases. Sensitive and accurate detection of bilirubin is of great significance for personal health care. The rapid development of fluorescent nanomaterials promotes rapid development in the bilirubin assay. In this review, traditional methods for detection of bilirubin are briefly presented to compare with fluorescent nanosensors. Subsequently, the recent progress of different types of fluorescent nanomaterials for determination of bilirubin is summarized. Further, the performance of fluorescent nanosensors and conventional techniques for sensing bilirubin are compared. To this end, the challenges and prospects concerning the topics are discussed. This review will provide some introductory knowledge for researchers to understand the status and importance of fluorescent nanosensors for sensing bilirubin.

血液中胆红素的积累与许多疾病有关。灵敏、准确地检测胆红素对个人保健具有重要意义。荧光纳米材料的快速发展促进了胆红素测定的快速发展。在这篇综述中，简要介绍了传统的胆红素检测方法，以与荧光纳米传感器进行比较。随后，总结了不同类型的荧光纳米材料测定胆红素的最新进展。此外，还比较了荧光纳米传感器的性能和用于检测胆红素的传统技术。为此，讨论了与这些主题相关的挑战和前景。