Cell-Laden Scaffolds for Vascular-Innervated Bone Regeneration,Advanced Healthcare Materials

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Cell-Laden Scaffolds for Vascular-Innervated Bone Regeneration
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-02-07 , DOI: 10.1002/adhm.202201923
Chen Qin _{1,

2} , Hongjian Zhang _{1,

2} , Lei Chen _{1,

2} , Meng Zhang _{1,

2} , Jingge Ma _{1,

2} , Hui Zhuang _{1,

2} , Zhiguang Huan _{1,

2} , Yin Xiao ₃ , Chengtie Wu _{1,

2}

Affiliation

For regeneration of highly vascularized and innervated tissues, like bone, simultaneous ingrowth of blood vessels and nerves is essential but largely neglected. To address this issue, a “pre-angiogenic” cell-laden scaffold with durable angiogenic functions is prepared according to the bioactivities of silicate bioceramics and the instructive effects of vascular cells on neurogenesis and bone repair. Compared with traditional cell-free scaffolds, the prepared cell-laden scaffolds printed with active cells and bioactive inks can support long-term cell survival and growth for three weeks. The long-lived scaffolds exhibited durable angiogenic capability both in vitro and in vivo. The pre-angiogenic scaffolds can induce the neurogenetic differentiation of neural cells and the osteogenic differentiation of mesenchymal stem cells by the synergistic effects of released bioactive ions and the ability of vascular cells to attract neurons. The enhanced bone regeneration with both vascularization and innervation is attributed to these physiological functions of the pre-angiogenic cell-laden scaffolds, which is defined as “vascular-innervated” bone regeneration. It is suggested that the concept of “vascular-innervated scaffolds” may represent the future direction of biomaterials for complex tissue/organ regeneration.

中文翻译：

用于血管神经支配的骨再生的细胞支架

对于高度血管化和神经支配的组织（如骨骼）的再生，血管和神经的同时向内生长至关重要，但在很大程度上被忽视了。为了解决这个问题，根据硅酸盐生物陶瓷的生物活性以及血管细胞对神经发生和骨修复的指导作用，制备了具有持久血管生成功能的“预血管生成”细胞支架。与传统的无细胞支架相比，用活性细胞和生物活性墨水印刷的制备的载细胞支架可以支持细胞长期存活和生长三周。长寿命支架在体外和体内均表现出持久的血管生成能力。预血管生成支架通过释放的生物活性离子和血管细胞吸引神经元的能力的协同作用，可以诱导神经细胞的神经分化和间充质干细胞的成骨分化。血管化和神经支配增强的骨再生归因于预血管生成细胞负载支架的这些生理功能，这被定义为“血管神经支配”骨再生。有人提出，“血管神经支架”的概念可能代表复杂组织/器官再生生物材料的未来方向。血管化和神经支配增强的骨再生归因于预血管生成细胞负载支架的这些生理功能，这被定义为“血管神经支配”骨再生。有人提出，“血管神经支架”的概念可能代表复杂组织/器官再生生物材料的未来方向。血管化和神经支配增强的骨再生归因于预血管生成细胞负载支架的这些生理功能，这被定义为“血管神经支配”骨再生。有人提出，“血管神经支架”的概念可能代表复杂组织/器官再生生物材料的未来方向。

更新日期：2023-02-07

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