A rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists to improve sophisticated molecules with a broad range of pharmacological activities. Thiophene and its synthetic derivatives are a prominent heterocyclic compound class with intriguing uses in medical chemistry. It has been manifesting to be an effective drug in current respective diseases scenario. It has been discovered that thiophene had an extensive spectrum of pharmacological potential with numerous applications in academic interest, in the pharmaceutical industry, material science, and medicinal chemistry. Antimitotic, antimicrobial, anti-inflammatory, anticonvulsant, antipsychotic, antiarrhythmic, anti-anxiety, antifungal, antioxidant, estrogen receptor regulating, and anti-cancer are one of the pharmacological and physiological activities of thiophene moiety. However, there are some marketed formulations available such as Thiophenfurin, Teniposide, Cefoxitin, Ticaconazole, Sertaconazole, Suprofen, ketotifen, Brinzolamide, Dorzolamide, Tiotropium which contain thiophene nucleus. Thus, in brief, gathering recent data is necessary to comprehend the present scenario of thiophene moiety for scientific research purposes and highlights a broad view of the biological potential of compounds having a thiophene nucleus.

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噻吩化合物的治疗潜力：小综述

越来越多的研究人员对基于噻吩的类似物感兴趣，因为它们在大力发展的杂环部分的化学世界中具有广泛的生物潜力。它在合成有机化学中也占有中心地位，具有最高的理论和实践重要性。它成为研究人员发现组合文库和实施寻找先导实体的重要组成部分。此外，它还可以帮助药物化学家改进具有广泛药理活性的复杂分子。噻吩及其合成衍生物是一类重要的杂环化合物，在医学化学中具有有趣的用途。它已被证明是治疗当前各种疾病的有效药物。人们发现噻吩具有广泛的药理学潜力，在学术兴趣、制药工业、材料科学和药物化学方面有广泛的应用。抗有丝分裂、抗菌、抗炎、抗惊厥、抗精神病、抗心律失常、抗焦虑、抗真菌、抗氧化、雌激素受体调节和抗癌是噻吩部分的药理和生理活性之一。然而，有一些市售制剂含有噻吩核，例如噻吩呋林、替尼泊苷、头孢西丁、替卡康唑、舍他康唑、舒洛芬、酮替芬、布林佐胺、多佐胺、噻托铵。因此，简而言之，收集最新数据对于理解噻吩部分的当前情况以用于科学研究目的是必要的，并强调具有噻吩核的化合物的生物潜力的广泛观点。