Extracorporeal therapy of sepsis by purified granulocyte concentrates: ex vivo circulation model,Artificial Organs

当前位置： X-MOL 学术 › Artif. Organs › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Extracorporeal therapy of sepsis by purified granulocyte concentrates: ex vivo circulation model
Artificial Organs ( IF 2.2 ) Pub Date : 2023-02-05 , DOI: 10.1111/aor.14507
Gerd Klinkmann ₁ , Thomas Wild ₂ , Benjamin Heskamp ₂ , Fanny Doss ₂ , Sandra Doss _{2,

3} , Magdalena Milej ₂ , Lea-Marie Thiele ₄ , Lilia Goudeva ₅ , Rainer Blasczyk ₅ , Daniel A Reuter ₁ , Jens Altrichter ₂ , Steffen Mitzner _{3,

4}

Affiliation

Immune cell dysfunction is a central part of immune paralysis in sepsis. Granulocyte concentrate (GC) transfusions can induce tissue damage via local effects of neutrophils. The hypothesis of an extracorporeal plasma treatment with granulocytes is to show beneficial effects with fewer side effects. Clinical trials with standard GC have supported this approach. This ex vivo study investigated the functional properties of purified granulocyte preparations during the extracorporeal plasma treatment.

中文翻译：

纯化粒细胞浓缩物体外治疗脓毒症：离体循环模型

免疫细胞功能障碍是脓毒症免疫麻痹的核心部分。浓缩粒细胞（GC）输注可通过中性粒细胞的局部作用引起组织损伤。粒细胞体外血浆治疗的假设是显示出有益的效果和更少的副作用。标准 GC 的临床试验支持了这种方法。这项离体研究研究了纯化粒细胞制剂在体外血浆处理过程中的功能特性。

更新日期：2023-02-05

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南