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Efficiency of cutaneous heat diffusion after local hyperthermia for the treatment of itch
Skin Research and Technology ( IF 2.0 ) Pub Date : 2023-02-01 , DOI: 10.1111/srt.13277 Johannes Wohlrab 1, 2 , Tim Mentel 3 , Adina Eichner 2
Skin Research and Technology ( IF 2.0 ) Pub Date : 2023-02-01 , DOI: 10.1111/srt.13277 Johannes Wohlrab 1, 2 , Tim Mentel 3 , Adina Eichner 2
Affiliation
Today, itching is understood as an independent sensory perception, which is based on a complex etiology of a disturbed neuronal activity and leads to clinical symptoms. The primary afferents (pruriceptors) have functional overlaps with afferents of thermoregulation (thermoceptors). Thus, an antipruritic effect can be caused by antagonizing heat-sensitive receptors of the skin. The ion channel TRP-subfamily V member 1 (TRPV1) is of particular importance in this context. Repeated heat application can induce irreversible inactivation by unfolding of the protein, causing a persistent functional deficit and thus clinically and therapeutically reducing itch sensation.
中文翻译:
局部热疗后皮肤热扩散治疗瘙痒的效果
如今,瘙痒被理解为一种独立的感觉知觉,它基于神经元活动紊乱的复杂病因并导致临床症状。初级传入神经(瘙痒感受器)与温度调节传入神经(温度感受器)有功能重叠。因此,止痒作用可以通过拮抗皮肤的热敏受体来引起。离子通道 TRP 亚家族 V 成员 1 (TRPV1) 在这方面尤其重要。重复加热可以通过蛋白质的展开诱导不可逆的失活,导致持续的功能缺陷,从而在临床和治疗上减少瘙痒感。
更新日期:2023-02-06
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
局部热疗后皮肤热扩散治疗瘙痒的效果
如今,瘙痒被理解为一种独立的感觉知觉,它基于神经元活动紊乱的复杂病因并导致临床症状。初级传入神经(瘙痒感受器)与温度调节传入神经(温度感受器)有功能重叠。因此,止痒作用可以通过拮抗皮肤的热敏受体来引起。离子通道 TRP 亚家族 V 成员 1 (TRPV1) 在这方面尤其重要。重复加热可以通过蛋白质的展开诱导不可逆的失活,导致持续的功能缺陷,从而在临床和治疗上减少瘙痒感。