Today, itching is understood as an independent sensory perception, which is based on a complex etiology of a disturbed neuronal activity and leads to clinical symptoms. The primary afferents (pruriceptors) have functional overlaps with afferents of thermoregulation (thermoceptors). Thus, an antipruritic effect can be caused by antagonizing heat-sensitive receptors of the skin. The ion channel TRP-subfamily V member 1 (TRPV1) is of particular importance in this context. Repeated heat application can induce irreversible inactivation by unfolding of the protein, causing a persistent functional deficit and thus clinically and therapeutically reducing itch sensation.

中文翻译：

---

局部热疗后皮肤热扩散治疗瘙痒的效果

如今，瘙痒被理解为一种独立的感觉知觉，它基于神经元活动紊乱的复杂病因并导致临床症状。初级传入神经（瘙痒感受器）与温度调节传入神经（温度感受器）有功能重叠。因此，止痒作用可以通过拮抗皮肤的热敏受体来引起。离子通道 TRP 亚家族 V 成员 1 (TRPV1) 在这方面尤其重要。重复加热可以通过蛋白质的展开诱导不可逆的失活，导致持续的功能缺陷，从而在临床和治疗上减少瘙痒感。