Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni [Microbiology],Proceedings of the National Academy of Sciences of the United States of America

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Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni [Microbiology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2016-09-20 08:46:01 , DOI: 10.1073/pnas.1605869113
Zuowei Wu ₁ , Balamurugan Periaswamy _{2,

3} , Orhan Sahin _{1,

4} , Michael Yaeger ₅ , Paul Plummer _{1,

4} , Weiwei Zhai ₃ , Zhangqi Shen ₁ , Lei Dai ₁ , Swaine L. Chen _{2,

3} , Qijing Zhang ₁

Affiliation

Infections due to clonal expansion of highly virulent bacterial strains are clear and present threats to human and animal health. Association of genetic changes with disease is now a routine, but identification of causative mutations that enable disease remains difficult. Campylobacter jejuni is an important zoonotic pathogen transmitted to humans...

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