Activatable Fluorescent Probes Targeting Urokinase-Type Plasminogen Activator Receptor on the Cell Membrane,Chemistry - A European Journal

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Activatable Fluorescent Probes Targeting Urokinase-Type Plasminogen Activator Receptor on the Cell Membrane
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-02-03 , DOI: 10.1002/chem.202203739
Tae-Il Kim ₁ , Siyoung Cho ₁ , Hanyong Jin ₂ , Jeehyeon Bae ₃ , Chanhee Park ₄ , Youngmi Kim ₁

Affiliation

Activatable fluorescent probes consisting of a donor-π-acceptor-based fluorophore conjugated with the uPAR-binding AE105 peptide effectively monitor uPAR levels in a “turn-on” mode. The application of the fluorescent “turn-on” probes is demonstrated in the imaging of uPAR overexpressed on the membrane of cancer cells and in a cell-based uPAR inhibitor assay.

中文翻译：

靶向细胞膜上尿激酶型纤溶酶原激活剂受体的可激活荧光探针

由与 uPAR 结合 AE105 肽缀合的基于供体-π-受体的荧光团组成的可激活荧光探针在“开启”模式下有效监测 uPAR 水平。荧光“开启”探针的应用在癌细胞膜上过表达的 uPAR 成像和基于细胞的 uPAR 抑制剂测定中得到证明。

更新日期：2023-02-03

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