p-Methoxybenzyl-Radical-Promoted Chemoselective Protection of sec-Alkylamides,The Journal of Organic Chemistry

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p-Methoxybenzyl-Radical-Promoted Chemoselective Protection of sec-Alkylamides
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-02-02 , DOI: 10.1021/acs.joc.2c02582
JingWen Jia ₁ , Terumasa Kato ₂ , Keiji Maruoka _{1,

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Affiliation

The hitherto difficult site-selective p-methoxybenzylation of secondary amides using p-methoxybenzylated alkylsilyl peroxides as a novel p-methoxybenzylation agent under copper catalysis is reported. The reaction proceeds under mild reaction conditions in a highly chemoselective manner. This approach was successfully applied to the site-selective p-methoxybenzylation of peptides.

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