Morita-Baylis-Hillman 加合物 (MBHA) 的生物活性,Mini-Reviews in Medicinal Chemistry

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Morita-Baylis-Hillman 加合物 (MBHA) 的生物活性
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2023-03-01 , DOI: 10.2174/1389557523666230202103719
Larissa Adilis Maria Paiva Ferreira ₁ , Louise Mangueira de Lima ₁ , Laercia Karla Diega Paiva Ferreira ₁ , Larissa Rodrigues Bernardo ₁ , Aleff Castro ₂ , Claudio Gabriel Lima Junior ₂ , Mário Luiz Araújo de Almeida Vasconcellos ₂ , Marcia Regina Piuvezam ₁

Affiliation

背景：Morita-Baylis-Hillman 反应 (MBHR) 被认为是用于碳-碳键形成的最强大、最通用的方法之一。该反应定义为亲电子碳 sp2 与带有吸电子基团的烯烃的 α 位在催化剂存在下发生缩合。该反应的优点是原子经济性高、反应条件温和。在理想条件下，该反应会形成多功能产物，称为 Morita-Baylis-Hillman 加合物 (MBHA)，这是一类表现出多种生物活性的相关分子。目的：考虑到这些化合物的重要性，本综述汇集了有关 MBHA 生物活性的几项研究，以指出这些分子作为未来治疗剂的用途。方法：我们检索了主要数据库中 1999 年至 2022 年发表的科学文章，使用描述符：Morita-Baylis-Hillman 加合物、Morita-Baylis-Hillman 反应、生物活性和生物潜力。结果：35 篇文章显示了 MBHA 的多种生物活性，包括杀软体动物、抗肿瘤、除草、杀真菌、抗利什曼药、抗氧化、抗疟、抗肿瘤炎症、血管舒张、抗恰加斯、抗菌和抗炎活性。结论：因此，通过进一步研究了解 MBHA 的有效作用机制，这些化合物有望成为治疗多种疾病的药物。

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Biological Activities of Morita-Baylis-Hillman Adducts (MBHA)

Background: The Morita-Baylis-Hillman reaction (MBHR) is considered one of the most powerful and versatile methodologies used for carbon-carbon bond formation. The reaction is defined as the condensation between an electrophilic carbon sp² and the α position of an olefin, carrying an electron-withdrawing group, in the presence of a catalyst. The advantages of the reaction are the high atom economy and mild reaction conditions. Under ideal conditions, this reaction leads to the formation of multifunctional products, called Morita-Baylis-Hillman adducts (MBHA), a class of relevant molecules that exhibit a variety of biological activities. Objective: Considering the importance of these compounds, this review brought together several studies regarding the biological activities of MBHA, to point out the use of these molecules as future therapeutic agents. Methods: We searched for scientific articles available in the main databases, published between 1999 and 2022, using the descriptors: Morita-Baylis-Hillman adducts, Morita-Baylis-Hillman reaction, biological activity, and biological potentiality. Results: Thirty-five articles showed the variety of biological activities of MBHA, including molluscicidal, antitumor, herbicidal, and fungicidal, antileishmanial, antioxidant, antimalarial, anti-tumor inflammatory, vasorelaxant, antichagasic, antimicrobial, and anti-inflammatory activities. Conclusion: Therefore, these compounds are promising candidates to become drugs for the treatment of a variety of diseases, following further studies to understand the effective mechanisms of action of MBHA.

更新日期：2023-03-01

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