Intrathymic dendritic cell (DC)-biased precursors act as hematopoietic stromal cells that support the generation of human T cell progenitors from hematopoietic progenitor cells, via crosstalk with immature thymocytes that express TNF receptor 2. This function of DC precursors can be exploited to generate T cell precursors and competent T cells for cell therapy.

中文翻译：

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树突状细胞偏向的前体支持早期人类胸腺生成

胸腺内树突状细胞 (DC) 偏向前体充当造血基质细胞，通过与表达 TNF 受体 2 的未成熟胸腺细胞串扰，支持从造血祖细胞生成人类 T 细胞祖细胞。DC 前体的这种功能可用于产生 T用于细胞治疗的细胞前体和感受态 T 细胞。