血管铸型以编程抗狭窄血流动力学和静脉移植物重塑,Advanced Science

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血管铸型以编程抗狭窄血流动力学和静脉移植物重塑
Advanced Science ( IF 14.3 ) Pub Date : 2023-02-02 , DOI: 10.1002/advs.202204993
Hyunsu Ha ₁ , Ju Young Park ₂ , Chan Hee Lee ₁ , Deok-Hyeon Son ₁ , Soon Won Chung ₃ , Sewoom Baek ₄ , Kyubae Lee ₁ , Kang Suk Lee ₂ , Se Won Yi ₂ , Mi-Lan Kang ₂ , Dae-Hyun Kim ₅ , Hak-Joon Sung _{1,

2,

4}

Affiliation

医疗器械的结构稳定性是通过管理响应于器官运动的应力分布来建立的。由于不匹配的组织特性，静脉在动脉移植后突然扩张，导致流动障碍，从而导致狭窄。血管模型旨在包裹静脉-动脉移植物，从而依靠弹性固定来调整直径和性能不匹配。在这里，铸造结构中的小桥接连接是防止由于改进的弹性固定而引起的应力集中的基本要素。因此，有效抑制静脉扩张，有效诱导健康（层流和螺旋）流动，促进静脉移植的健康功能，如内皮细胞与动脉化、肌肉扩张的流动方向对齐所示，并改善收缩力。最后，桥的协同效应极大地抑制了狭窄并改善了通畅性。作为关键技术点，通过流固相互作用的计算模型验证了加桥的优势，然后进行了定制的离体设置和分析。使用一系列针对翻译的细胞、大鼠和犬类模型验证了计算出的效果。这座桥就像“荷兰小男孩”一样，通过支持 cast 功能，用一根手指拯救了大团块。使用一系列针对翻译的细胞、大鼠和犬类模型验证了计算出的效果。这座桥就像“荷兰小男孩”一样，通过支持 cast 功能，用一根手指拯救了大团块。使用一系列针对翻译的细胞、大鼠和犬类模型验证了计算出的效果。这座桥就像“荷兰小男孩”一样，通过支持 cast 功能，用一根手指拯救了大团块。

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Vascular Cast to Program Antistenotic Hemodynamics and Remodeling of Vein Graft

The structural stability of medical devices is established by managing stress distribution in response to organ movement. Veins abruptly dilate upon arterial grafting due to the mismatched tissue property, resulting in flow disturbances and consequently stenosis. Vascular cast is designed to wrap the vein-artery grafts, thereby adjusting the diameter and property mismatches by relying on the elastic fixity. Here, a small bridge connection in the cast structure serves as an essential element to prevent stress concentrations due to the improved elastic fixity. Consequently, the vein dilation is efficiently suppressed, healthy (laminar and helical) flow is induced effectively, and the heathy functions of vein grafting are promoted, as indicated by the flow directional alignment of endothelial cells with arterialization, muscle expansion, and improved contractility. Finally, collaborative effects of the bridge drastically suppress stenosis with patency improvement. As a key technical point, the advantages of the bridge addition are validated via the computational modeling of fluid–structure interaction, followed by a customized ex vivo set-up and analyses. The calculated effects are verified using a series of cell, rat, and canine models towards translation. The bridge acted like “Little Dutch boy” who saved the big mass using one finger by supporting the cast function.

更新日期：2023-02-02

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