The Jiaodong Peninsula is the most important gold province in China, and the Liaoshang gold deposit represents a major recent prospecting breakthrough in Jiaodong. Based on detailed metallographic and microstructural observations, and He-Ar-Pb isotope compositions of fluid inclusions from main-ore-stage pyrite were presented, as well as the CO isotope compositions of main-ore-stage dolomite. Fluid inclusions from the pyrite have ³He = 1.18 – 8.69 × 10^-14 cm³STP/g, ⁴He = 1.21 – 3.24 × 10^-7 cm³STP/g, and ³He/⁴He = 0.12 – 0.81 Ra, and the ore-forming fluid was mainly crustal-sourced with mantle fluid input. The fluid inclusions have ⁴⁰Ar = 5.42 – 1.87 × 10^-7 cm³STP/g, ⁴⁰Ar/³⁶Ar = 328.5 – 511.3, close to saturated meteoric water ⁴⁰Ar/³⁶Ar value. It is speculated that the crustal-sourced ore fluid may have had meteoric water input in the mineralization. The main-ore-stage dolomite contains δ¹³C = -2.9 to −4.4 ‰ and δ¹⁸O_V-SMOW = 10.5 to 11.3 ‰. It is speculated that the carbon was mainly deep magmatic fluid- or magma-sourced. The pyrite has ²⁰⁶Pb/²⁰⁴Pb = 17.244 – 17.416, ²⁰⁷Pb/²⁰⁴Pb = 15.448 – 15.462, ²⁰⁸Pb/²⁰⁴Pb = 37.824 – 37.950, and ²⁰⁶Pb/²⁰⁷Pb = 1.116 – 1.125, indicating that the ore-forming materials were derived from a crust-mantle-mixed source, which we considered to be the Linglong granite and the Jiaodong (or Jingshan) Group wallrocks. We conclude that the ore-forming fluids and materials at Liaoshang have multiple and complex sources, and that the Mesozoic tectono-magmatic activities have a clear control on the formation and distribution of the Liaoshang gold orebodies..