ILC2 和 Th2 细胞之间的串扰因小鼠模型而异,Cell Reports

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ILC2 和 Th2 细胞之间的串扰因小鼠模型而异
Cell Reports ( IF 7.5 ) Pub Date : 2023-02-02 , DOI: 10.1016/j.celrep.2023.112073
Rama K Gurram ₁ , Danping Wei ₂ , Qiao Yu ₃ , Matthew J Butcher ₂ , Xi Chen ₂ , Kairong Cui ₄ , Gangqing Hu ₅ , Mingzhu Zheng ₂ , Xiaoliang Zhu ₂ , Jangsuk Oh ₆ , Bing Sun ₇ , Joseph F Urban ₈ , Keji Zhao ₄ , Warren J Leonard ₆ , Jinfang Zhu ₂

Affiliation

Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Gerontology and Respirology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
US Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705, USA.

2 型 T 辅助细胞 (Th2) 和 2 类先天淋巴细胞 (ILC2) 可提供针对蠕虫感染的保护作用，并参与过敏反应。然而，它们在 2 型免疫反应中的相对重要性和串扰仍然存在争议。通过生成和利用缺乏 ILC2 或 Th2 细胞的小鼠品系，我们报告白细胞介素 (IL)-33 介导的 ILC2 激活可促进 Th2 细胞对木瓜蛋白酶的反应；然而，Th2 细胞对卵清蛋白 (OVA)/明矾免疫的反应依赖于胸腺基质淋巴细胞生成素 (TSLP)，但独立于 ILC2。在蠕虫感染期间，ILC2 和 Th2 细胞在免疫反应的不同阶段进行协作。Th2细胞主要通过IL-4的产生，诱导IL-25、IL-33和TSLP的表达，其中IL-25和IL-33冗余地促进ILC2扩增。因此，虽然 Th2 细胞分化可以独立于 ILC2 发生，但 ILC2 的激活可能会促进 Th2 反应，并且 Th2 细胞可以通过诱导 2 型警报素来扩增 ILC2。

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更新日期：2023-02-02

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