Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction,Advanced Drug Delivery Reviews

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Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2023-02-02 , DOI: 10.1016/j.addr.2023.114722
Shaobao Liu ₁ , Yuan Li ₂ , Yuan Hong ₃ , Ming Wang ₂ , Hao Zhang ₁ , Jinlu Ma ₄ , Kai Qu ₅ , Guoyou Huang ₆ , Tian Jian Lu ₁

Affiliation

State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics, Nanjing 210016, PR China.
MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China.
MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China; National Science Foundation Science and Technology Center for Engineering Mechanobiology, Washington University, St. Louis, MO 63130, USA.
Department of Radiation Oncology, the First Affiliated Hospital, Xian Jiaotong University, Xi'an 710061, PR China.
Department of Hepatobiliary Surgery, the First Affiliated Hospital, Xian Jiaotong University, Xi'an 710061, PR China.
Department of Engineering Mechanics, School of Civil Engineering, Wuhan University, Wuhan 430072, PR China.

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.

中文翻译：

肿瘤学中的机械疗法：靶向核力学和机械传导

机械疗法被提议作为癌症治疗的新选择。越来越多的证据表明，与正常细胞相比，癌细胞的核力学和机械传导存在特征差异。理解核力学和机械传导的最新进展不仅为恶性转化过程提供了进一步的见解，而且为开发新的治疗方法提供了有用的参考。在此，我们概述了癌细胞中核力学和机械传导的改变，并强调了它们在癌症机械治疗中的意义。

更新日期：2023-02-02

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