Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins,Angewandte Chemie International Edition

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Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-02-01 , DOI: 10.1002/anie.202218106
Yuqi Wu ₁ , Bingqian Lin ₂ , Yinzhu Lu ₁ , Liang Li ₁ , Kunyue Deng ₁ , Suhui Zhang ₁ , Huiming Zhang ₃ , Chaoyong Yang _{1,

3} , Zhi Zhu ₁

Affiliation

Aptamer-LYTACs have been developed by conjugating aptamers to tri-GaINAc to realize liver-cell-specific degradation of extracellular and membrane proteins. This platform can efficiently and quickly degrade the extracellular protein PDGF and the membrane protein PTK7 through the lysosomal degradation pathway, providing a new method for targeted protein degradation.

中文翻译：

Aptamer-LYTACs 用于细胞外和膜蛋白的靶向降解

Aptamer-LYTACs 是通过将适体与 tri-GaINAc 结合来开发的，以实现细胞外和膜蛋白的肝细胞特异性降解。该平台可通过溶酶体降解途径高效快速地降解细胞外蛋白PDGF和膜蛋白PTK7，为靶向蛋白降解提供了一种新方法。

更新日期：2023-02-01

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