Fitoterapia ( IF 2.5 ) Pub Date : 2023-02-01 , DOI: 10.1016/j.fitote.2023.105441 Feihe Lian 1 , Jun Chi 1 , Qionglin Meng 1 , Qingxia Li 1 , Anying Chen 1 , Zhimin Wang 2 , Liping Dai 1
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Six new cucurbitane-type triterpenes, hemchinins A-F (1–6), together with thirteen known ones (7–19) were isolated from ethyl acetate extraction of Hemsleya chinensis tubers. Compounds 1–2 were a group of cucurbitane triterpenes possessing an infrequent pentacyclic framework. Their structures were established by comprehensive UV, IR, HRMS, 1D/2D NMR, and ECD analyses. Bioassay results showed that most isolated compounds exhibited anti-inflammatory actions, in which compounds 13 and 15 exhibited stronger activities at 6.25 μM, with NO inhibition rates of 49.00 ± 0.05% and 48.40 ± 0.10%, respectively.
中文翻译：
雪茄块茎中的葫芦烷三萜及其抗炎活性
从雪茄块茎的乙酸乙酯提取物中分离出六种新的葫芦烷型三萜类化合物 hemchinins AF ( 1–6 ) 以及十三种已知的 ( 7–19 ) 。化合物1-2是一组葫芦烷三萜，具有罕见的五环骨架。它们的结构是通过综合 UV、IR、HRMS、1D/2D NMR 和 ECD 分析确定的。生物测定结果表明，大多数分离的化合物表现出抗炎作用，其中化合物13和15在 6.25 μM 时表现出更强的活性，NO 抑制率分别为 49.00 ± 0.05% 和 48.40 ± 0.10%。
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