氧杂蒽酮：一类具有抗癌潜力的杂环化合物,Current Topics in Medicinal Chemistry

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氧杂蒽酮：一类具有抗癌潜力的杂环化合物
Current Topics in Medicinal Chemistry ( IF 2.9 ) Pub Date : 2022-09-03 , DOI: 10.2174/1568026622666220901145002
Abdur Rauf ₁ , Muthu Thiruvengadam ₂ , Somia Gul ₃ , Khadija Aslam ₃ , Quratulain Pirzada ₃ , Anees Ahmed Khalil ₄ , Prabhakar Semwal ₅ , Sami Bawazeer ₆ , Yahya S. Al-Awthan _{7,

8} , Omar Bahattab ₇ , Mohammed A. Al-Duais _{9,

10}

Affiliation

Department of Chemistry, University of Swabi, Swabi, Anbar, 23430, Khyber Pakhtunkhwa (KP), Pakistan
Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 05029, Republic of Korea
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi-74600, Pakistan
University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan
Department of Life Sciences, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India
Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Saudi Arabia
Department of Biology, Faculty of Science. University of Tabuk, Tabuk, Saudi Arabia
Department of Biology, Faculty of Science, Ibb University, Ibb, Yemen
Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia
Biochemistry Unit, Chemistry Department, Faculty of Science, Ibb University, Ibb, Yemen

: Xanthones (9H xanthen-9-one) 是一类重要的含有氧和γ-吡酮部分的杂环化合物，具有致密的双苯环结构，广泛分布于自然界。天然存在的氧杂蒽酮作为真菌和地衣中的次级代谢产物存在于微生物和高等植物中。Calophyllaceae、Guttiferae 和龙胆科的化合物是氧杂蒽酮最常见的天然来源。呫吨酮核的结构及其生物来源决定了碳是根据生物合成协定编号的。早期呫吨酮的特征氧化模式是莽草酸-乙酸混合生物合成。主要类别的氧杂蒽酮包括简单含氧、非氧合、木素木素、双氧杂蒽酮、异戊二烯化和相关氧杂蒽酮，以及杂项氧杂蒽酮。科学家们高度鼓励它们具有重要的药理学意义和有趣的支架，以研究用于癌症治疗的合成设计或天然产物。由于目前使用的抗肿瘤药物具有高毒性和低选择性，可能会影响有效治疗。本综述仅限于氧杂蒽酮的抗肿瘤活性和氧杂蒽酮核心的化学性质，这可能有助于为药物化学家提供基础知识，以进行新的和高级的药物开发研究。

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Xanthones: A Class of Heterocyclic Compounds with Anticancer Potential

: Xanthones (9H xanthen-9-one) are an important class of heterocyclic compounds containing oxygen and moiety of gamma-pirone, dense with a two-benzene ring structured, distributed widely in nature. Naturally occurring xanthones are found in micro-organisms and higher plants as secondary metabolites in fungi and lichens. Compounds of the family Calophyllaceae, Guttiferae and Gentianaceae are the most common natural source of xanthones. The structure of xanthones nucleus, coupled with its biogenetic source, imposes that the carbons are numbered according to the biosynthetic pact. The characteristics oxygenation pattern of xanthones earlier is mixed shikimate-acetate biogenesis. The major class of xanthones includes simple oxygenated, non-oxygenated, xanthonolignoids, bisxanthones, prenylated and related xanthones, as well as miscellaneous xanthones. Their great pharmacological importance and interesting scaffolds were highly encouraged by scientists to investigate either the synthesis design or natural products for cancer treatment. Because currently used antitumor drugs possess high toxicity and low selectivity, efficacious treatment may be compromised. This review is limited to the antitumor activity of xanthones and the chemistry of xanthone core, which may help provide fundamental knowledge to the medicinal chemist for new and advanced research in drug development.

更新日期：2022-09-03

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