嘧啶衍生物的构效关系及其生物活性 - 综述,Medicinal Chemistry

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嘧啶衍生物的构效关系及其生物活性 - 综述
Medicinal Chemistry ( IF 1.9 ) Pub Date : 2022-05-11 , DOI: 10.2174/1573406418666220509100356
Helina Navis Anthoni Samy ₁ , Ramalakshmi Natarajan ₁ , Amuthalakshmi Sivaperuman ₁ , Arunkumar Subramani ₂

Affiliation

背景：杂环化合物在氨基酸、DNA碱基、维生素、内源性神经递质等许多生物化学和生理领域中起着重要作用。含氮杂环化合物在药物化学中起着至关重要的作用，具有显着的生物和药理活性。在过去的二十年里，科学家们更多地关注嘧啶衍生物的多样性生物活性。嘧啶是一种六元杂环化合物，天然存在于核酸成分（尿嘧啶、胸腺嘧啶、胞嘧啶）和维生素B1中；它是一种很有前途的先导分子，可用于合成具有各种取代基的化合物来治疗各种疾病。目的：重点研究2010年至今报道的嘧啶衍生物的构效关系及其各种生物活性。结果：从这篇综述中，我们得出结论，嘧啶核中取代基的位置对生物活性有很大影响。因此，嘧啶核显示出抗微生物、抗癌、抗炎、抗结核、抗惊厥、降压、驱虫、抗抑郁、镇痛、抗高血糖等活性。结论：本研究提供了嘧啶核的概述及其衍生产品从 2010 年至今。未来有为目标生物活性鉴定先导分子的范围。抗高血糖活性等。结论：本研究概述了 2010 年至今的嘧啶核及其衍生物。未来有为目标生物活性鉴定先导分子的范围。抗高血糖活性等。结论：本研究概述了 2010 年至今的嘧啶核及其衍生物。未来有为目标生物活性鉴定先导分子的范围。

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Structure-Activity Relationships of Pyrimidine Derivatives and their Biological Activity - A Review

Background: Heterocycles play a major role in many fields of biochemical and physiological such as amino acids, DNA bases, vitamins, endogenous neurotransmitters, etc. Nitrogencontaining heterocyclic compounds play a vital role in medicinal chemistry and exhibit notable biological and pharmacological activities. In the past two decades, scientists focused more on the diverse biological activities of pyrimidine derivatives. Pyrimidine is a six-membered heterocyclic compound, and it is present naturally in nucleic acid components (uracil, thymine, and cytosine) and vitamin B1; it is a promising lead molecule for synthesising compounds with various substitutions to treat various diseases. Objective: We focused on the structure-activity relationship of pyrimidine derivatives and its various biological activities reported from 2010 to date. Results: From this review, we concluded that the position of substituents in the pyrimidine nucleus greatly influences biological activities. Thus, the pyrimidine nucleus showed anti-microbial, anticancer, anti-inflammatory, anti-tubercular, anti-convulsant, antihypertensive, anthelmintic, antidepressant, analgesic, anti-hyperglycemic activities, etc. Conclusion: This study provides an overview of the pyrimidine nucleus and its derivatives from 2010 to date. There is a future scope for identifying a lead molecule for the target biological activity.

更新日期：2022-05-11

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