Abstract

[1,2,4]Triazolo[4,3-c]quinazolines bearing p-bromophenyl or 5-bromothiophen-2-yl moiety at position 5 have been synthesized by cyclocondensation of the corresponding 4-hydrazinoquinazolines with ortho esters in boiling ethanol or glacial acidic acid. The synthesized tricyclic derivatives represent valuable intermediates for design of fluorophores and biologically active compounds. The possibility of modifying 5-(4-bromophenyl) derivatives by cross-coupling reaction has been demonstrated.

中文翻译：

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5-芳基/噻吩基-[1,2,4]三唑并[4,3-c]喹唑啉新型衍生物的合成

摘要

[1,2,4]三唑并[4,3 - c ]喹唑啉在第 5 位带有对溴苯基或 5-溴噻吩-2-基部分，通过相应的 4-肼基喹唑啉与原酸酯在沸腾乙醇或冰川酸。合成的三环衍生物代表了用于设计荧光团和生物活性化合物的有价值的中间体。通过交叉偶联反应修饰 5-(4-溴苯基) 衍生物的可能性已经得到证明。