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Chemical constituents and cytotoxicity of Lepidotrigona ventralis propolis
Vietnam Journal of Chemistry Pub Date : 2023-01-27 , DOI: 10.1002/vjch.202200031
Le Nguyen Thanh 1 , Nguyen Anh Thu 1 , Vu Thi Kim Oanh 1 , Vu Thi Hue 1 , Nguyen Tu Minh 2 , Nguyen Phan Ngoc Minh 2 , Truong Vinh Xuan 2 , Diep Thi Lan Phuong 3 , Nguyen Thi Phuong Lien 4
Affiliation  

From propolis of Lepidotrigona ventralis stingless bee collected in Tuyen Quang province, eight compounds were isolated and determined as lantanolic acid (1), moronic acid (2), (+)-eudesmin (3), (+)-yangambin (4), (+)-syringaresinol (5), (+)-pinoresinol (6), dihydroconiferyl alcohol (7) and vanillin (8) using NMR and MS spectral data. Compounds 1 and 2 showed significant cytotoxicity against HepG-2 cancer cell line with IC50 values of 25.84±0.48 and 39.92±1.14 μg/mL, respectively.

中文翻译:

Lepidotrigona ventralis 蜂胶的化学成分和细胞毒性

从宣光省采集的Lepidotrigona ventralis ventralis无刺蜂蜂胶中,分离并测定了 8 种化合物,分别为羊毛醇酸 ( 1 )、莫糖酸 ( 2 )、(+)-eudesmin (3)、(+)-yangabin (4)、 (+)-丁香脂酚(5)、(+)-松脂醇(6)、二氢松柏醇(7)和香兰素(8),使用 NMR 和 MS 光谱数据化合物12显示出对HepG-2癌细胞系的显着细胞毒性,IC 50值分别为25.84±0.48和39.92±1.14μg/mL。
更新日期:2023-01-27
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