Covalent Organic Frameworks: Recent Progress in Biomedical Applications,ACS Nano

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Covalent Organic Frameworks: Recent Progress in Biomedical Applications
ACS Nano ( IF 15.8 ) Pub Date : 2023-01-30 , DOI: 10.1021/acsnano.2c11346
Yongqiang Shi _{1,

2} , Jinglun Yang ₂ , Feng Gao ₁ , Qichun Zhang _{2,

3}

Affiliation

Covalent organic frameworks (COFs) are a type of crystalline organic porous material with specific features and interesting structures, including porosity, large surface area, and biocompatibility. These features enable COFs to be considered as excellent candidates for applications in various fields. Recently, COFs have been widely demonstrated as promising materials for biomedical applications because of their excellent physicochemical properties and ultrathin structures. In this review, we cover the recent progress of COF materials for applications in photodynamic therapy, gene delivery, photothermal therapy, drug delivery, bioimaging, biosensing, and combined therapies. Moreover, the critical challenges and further perspectives with regards to COFs for future biology-facing applications are also discussed.

中文翻译：

共价有机框架：生物医学应用的最新进展

共价有机框架 (COF) 是一种结晶有机多孔材料，具有特定的特征和有趣的结构，包括孔隙率、大表面积和生物相容性。这些特性使 COF 被认为是各个领域应用的优秀候选者。最近，COFs因其优异的物理化学性质和超薄结构而被广泛证明是一种有前途的生物医学应用材料。在这篇综述中，我们介绍了 COF 材料在光动力疗法、基因传递、光热疗法、药物传递、生物成像、生物传感和联合疗法中应用的最新进展。此外，还讨论了未来面向生物学应用的 COF 的关键挑战和进一步的前景。

更新日期：2023-01-30

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