Aptamer (Apt) is a kind of recognition molecule with excellent affinity and high specificity. Transmembrane glycoprotein mucin (MUC1) is an important tumor biomarker overexpressed in MCF-7 tumor cells. MUC1 Apt (Apt-M) could specifically target MCF-7 tumor cells. Ti₃C₂ nanosheets with high photothermal conversion efficiency were considered as a promising therapeutic nanoplatform for tumor therapy. Doxorubicin (DOX) is a common anti-tumor drug. Herein, a novel DOX/Ti₃C₂/Apt-M therapeutic nanoplatform was successfully fabricated, which could specifically target MCF-7 tumor cells. As expected, the temperature of DOX/Ti₃C₂/Apt-M therapeutic nanoplatform raised rapidly under laser irradiation. Meanwhile, chemotherapy was triggered through multimodal stimuli-responsive drug release from the DOX/Ti₃C₂/Apt-M therapeutic nanoplatform under acidic environment and laser-induced local high temperature. Encouragingly, the MCF-7 cell viability of DOX/Ti₃C₂/Apt-M with laser irradiation was only 26.9%. The tumor surface temperature of MCF-7 xenograft mice in the DOX/Ti₃C₂/Apt-M + Laser group rose to about 58.3 °C, which was significantly higher than other laser irradiation groups. The experiments in vitro and in vivo indicated that the DOX/Ti₃C₂/Apt-M therapeutic nanoplatform can rapidly accumulate in MCF-7 tumors with excellent active targeting properties, and display superior tumor suppressive ability through combination therapy. This work provides a new idea of targeted tumor therapy based on Ti₃C₂ nanosheets.

适配体(Apt)是一类具有优良亲和力和高度特异性的识别分子。跨膜糖蛋白粘蛋白 (MUC1) 是一种重要的肿瘤生物标志物，在 MCF-7 肿瘤细胞中过表达。MUC1 Apt (Apt-M) 可以特异性靶向 MCF-7 肿瘤细胞。具有高光热转换效率的Ti ₃ C ₂纳米片被认为是用于肿瘤治疗的有前途的治疗性纳米平台。阿霉素（DOX）是一种常见的抗肿瘤药物。在此，成功制备了一种新型DOX/Ti ₃ C ₂ /Apt-M治疗性纳米平台，可特异性靶向MCF-7肿瘤细胞。正如预期的那样，DOX/Ti ₃ C _2的温度/Apt-M 治疗性纳米平台在激光照射下迅速升高。同时，在酸性环境和激光诱导的局部高温下，DOX/Ti ₃ C ₂ /Apt-M 治疗性纳米平台通过多模式刺激响应药物释放触发化疗。_{令人鼓舞的是，激光照射的 DOX/Ti 3} C ₂ /Apt-M的 MCF-7 细胞存活率仅为 26.9%。_{DOX/Ti 3} C ₂ /Apt-M + 激光组MCF-7移植瘤小鼠肿瘤表面温度升至58.3℃左右，显着高于其他激光照射组。体内外实验表明，DOX/ Ti ₃C ₂ /Apt-M治疗性纳米平台可以在MCF-7肿瘤中快速积累，具有优异的主动靶向特性，通过联合治疗显示出优越的肿瘤抑制能力。该工作为基于Ti ₃ C ₂纳米片的肿瘤靶向治疗提供了新思路。