Multiple Polymersomes for Programmed Release of Multiple Components,Journal of the American Chemical Society

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Multiple Polymersomes for Programmed Release of Multiple Components
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2011-09-28 , DOI: 10.1021/ja205687k
Shin-Hyun Kim ₁ , Ho Cheung Shum _{1,

2} , Jin Woong Kim ₃ , Jun-Cheol Cho ₄ , David A. Weitz ₁

Affiliation

Long-term storage and controlled release of multiple components while avoiding cross-contamination have potentially important applications for pharmaceuticals and cosmetics. Polymersomes are very promising delivery vehicles but cannot be used to encapsulate multiple independent components and release them in a controlled manner. Here, we report a microfluidic approach to produce multiple polymersomes, or polymersomes-in-polymersome by design, enabling encapsulation and programmed release of multiple components. Monodisperse polymersomes are prepared from templates of double-emulsion drops, which in turn are injected as the innermost phase to form the second level of double-emulsion drops, producing double polymersomes. Using the same strategy, higher-order polymersomes are also prepared. In addition, incorporation of hydrophobic homopolymer into the different bilayers of the multiple polymersomes enables controlled and sequential dissociation of the different bilayer membranes in a programmed fashion. The high encapsulation efficiency of this microfluidic approach, as well as its programmability and the biocompatibility of the materials used to form the polymersomes, will provide new opportunities for practical delivery systems of multiple components.

中文翻译：

用于程序化释放多种成分的多种聚合物体

多种成分的长期储存和控制释放同时避免交叉污染对于药物和化妆品具有潜在的重要应用。聚合物体是非常有前途的载体，但不能用于封装多个独立的成分并以受控方式释放它们。在这里，我们报告了一种通过设计生产多个聚合物囊泡或聚合物囊泡中的聚合物囊泡的微流体方法，从而实现多种成分的封装和程序释放。单分散聚合物囊泡是由双乳液滴剂的模板制备的，然后将其作为最内相注入以形成第二级双乳液滴剂，从而产生双聚合物囊泡。使用相同的策略，还制备了更高阶的聚合物囊泡。此外，将疏水性均聚物掺入多个聚合物囊泡的不同双层中能够以程序化的方式控制和顺序地分离不同的双层膜。这种微流体方法的高封装效率，以及它的可编程性和用于形成聚合物囊泡的材料的生物相容性，将为多组分的实际递送系统提供新的机会。

更新日期：2011-09-28

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