磷脂酰胆碱和溶血磷脂酰胆碱的体内水平是否可能是肥胖的可靠生物标志物？人类研究综述,Molecular Nutrition & Food Research

当前位置： X-MOL 学术 › Mol. Nutr. Food Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

磷脂酰胆碱和溶血磷脂酰胆碱的体内水平是否可能是肥胖的可靠生物标志物？人类研究综述
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2023-01-27 , DOI: 10.1002/mnfr.202200568
Paula Emília Nunes Ribeiro Bellot ₁ , Melissa Nunes Moia ₁ , Bruna Zavarize Reis _{1,

2} , Lucia Fatima Campos Pedrosa _{1,

2} , Ljubica Tasic ₃ , Fernando Barbosa ₄ , Karine Cavalcanti Maurício Sena-Evangelista _{1,

2}

Affiliation

磷脂酰胆碱 (PC) 是动物生物膜的主要成分，是一类以胆碱为首基的磷脂。溶血磷脂酰胆碱 (LPC) 是一类源自 PC 裂解的脂质生物分子，是参与动脉粥样硬化发病机制的氧化低密度脂蛋白 (oxLDL) 的主要成分。由于肥胖与慢性低度炎症状态相关，因此可以预期在这种情况下脂质组学特征会发生变化，并且 PC 和 LPC 作为肥胖的假设可靠生物标志物而受到关注。因此，对 PubMed、拉丁美洲和加勒比健康科学文献 (LILACS) 和 Excerpta Medica 数据库 (Embase) 进行了文献检索，以获得人口研究的结果，以澄清这一假设。检索策略共产生 2403 份报告，根据合格标准纳入 21 项研究。已经确定了关于 PC 和 LPC 与体重指数 (BMI) 和体脂参数关联的有争议的数据。BMI 与大多数 PC 物种之间存在反比关系，并且大多数研究表明 BMI 与 LPC 之间呈负相关。介绍了有关 PC 和 LPC 在肥胖方面差异的其他发现，并详细讨论了相关的不确定性。BMI 与大多数 PC 物种之间存在反比关系，并且大多数研究表明 BMI 与 LPC 之间呈负相关。介绍了有关 PC 和 LPC 在肥胖方面差异的其他发现，并详细讨论了相关的不确定性。BMI 与大多数 PC 物种之间存在反比关系，并且大多数研究表明 BMI 与 LPC 之间呈负相关。介绍了有关 PC 和 LPC 在肥胖方面差异的其他发现，并详细讨论了相关的不确定性。

"点击查看英文标题和摘要"

Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies

Phosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low-density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detail.

更新日期：2023-01-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南