程序性细胞死亡与免疫原性细胞死亡的相互关系——以抗肿瘤纳米药物为例,Small Methods

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程序性细胞死亡与免疫原性细胞死亡的相互关系——以抗肿瘤纳米药物为例
Small Methods ( IF 10.7 ) Pub Date : 2023-01-27 , DOI: 10.1002/smtd.202201406
Qi Meng _{1,

2} , Binbin Ding ₁ , Ping'an Ma _{1,

2} , Jun Lin _{1,

2}

Affiliation

程序性细胞死亡（PCD，主要包括细胞凋亡、坏死、铁死亡、细胞焦亡和自噬）和免疫原性细胞死亡（ICD）作为重要的细胞死亡机制，在癌症治疗中被广泛报道，了解两者之间的关系对癌症治疗具有重要意义临床肿瘤治疗。考虑到大量纳米药物被开发用于同时诱导肿瘤 PCD 和 ICD，在这篇综述中，以纳米药物为例描述了 PCD 和 ICD 之间的相互关系。首先，提供了 PCD 模式的概述，并重点介绍了它们之间的形态差异和相互联系。然后通过介绍各种癌症治疗方法和具有诱导免疫原性的纳米药物的最新发展，描述了细胞凋亡与内质网应激方面的 ICD 之间的相互关系。下一个，介绍了非凋亡（包括坏死、铁死亡、细胞焦亡和自噬）信号通路与ICD之间的串扰，并通过各种纳米药物为例进一步说明了它们之间的关系。最后总结了PCD与ICD的关系及其在新型ICD纳米材料开发中的应用前景。相信该综述将加深对PCD与ICD关系的认识，拓展各类纳米药物的生物医学应用，推动临床肿瘤治疗的进步。综述了PCD与ICD的关系及其在新型ICD纳米材料开发中的应用前景。相信该综述将加深对PCD与ICD关系的认识，拓展各类纳米药物的生物医学应用，推动临床肿瘤治疗的进步。综述了PCD与ICD的关系及其在新型ICD纳米材料开发中的应用前景。相信该综述将加深对PCD与ICD关系的认识，拓展各类纳米药物的生物医学应用，推动临床肿瘤治疗的进步。

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Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) and immunogenic cell death (ICD), as important cell death mechanisms, are widely reported in cancer therapy, and understanding the relationship between the two is significant for clinical tumor treatments. Considering that vast nanodrugs are developed to induce tumor PCD and ICD simultaneously, in this review, the interrelationship between PCD and ICD is described using nanomedicines as examples. First, an overview of PCD patterns and focus on the morphological differences and interconnections among them are provided. Then the interrelationship between apoptosis and ICD in terms of endoplasmic reticulum stress is described by introducing various cancer treatments and the recent developments of nanomedicines with inducible immunogenicity. Next, the crosstalk between non-apoptotic (including necrosis, ferroptosis, pyroptosis, and autophagy) signaling pathways and ICD is introduced and their relationship through various nanomedicines as examples is further illustrated. Finally, the relationship between PCD and ICD and its application prospects in the development of new ICD nanomaterials are summarized. This review is believed to deepen the understanding of the relationship between PCD and ICD, extend the biomedical applications of various nanodrugs, and promote the progress of clinical tumor therapy.

更新日期：2023-01-27

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