In order to improve the hemostatic effect of the hemostatic dressing for non-compressible wounds, unknown bleeding points and irregularly shaped wounds, a self-gelling hemostasis powder based on polyacrylic acid/polyacrylamide/quaternate chitosan (PAA/PAM/QCS) is prepared in this study. When in contact with water, the PAA/PAM/QCS can fuse and rapidly form a stable hydrogel in a short time (< 0.25 min). The PAA/PAM ratio is the main parameter that modulates the formation of the self-gel. The PAA/PAM self-gel can be formed only when the PAA/PAM ratio is 5:5, and the introduction of QCS does not influence the self-gelling behaviors and hydrogel stability. Moreover, the PAA/PAM/QCS self-gel shows good adhesive properties on wet tissue surfaces. In addition, the introduction of QCS improves the antibacterial activity of the self-gelling hemostasis powder. Furthermore, the prepared PAA/PAM/QCS powder can rapidly adsorb lots of blood, aggregate blood cells and platelets. The hemostatic results in vivo show that PAA/PAM/QCS powder is superior to the control group and commercial product groups (chitosan powder) with performance similar to hemostatic zeolite in terms of the amount of bleeding and hemostatic time. Therefore, the PAA/PAM/QCS self-gelling powder shows great application prospects for rapid hemostasis.

为了提高止血敷料对不可压缩伤口、出血点不明及形状不规则伤口的止血效果，制备了一种基于聚丙烯酸/聚丙烯酰胺/壳聚糖季铵盐(PAA/PAM/QCS)的自胶凝止血粉。这项研究。当与水接触时，PAA/PAM/QCS可以在短时间内（<0.25分钟）融合并快速形成稳定的水凝胶。 PAA/PAM 比例是调节自凝胶形成的主要参数。只有当PAA/PAM比例为5:5时，PAA/PAM才能形成自凝胶，并且QCS的引入不影响自凝胶行为和水凝胶稳定性。此外，PAA/PAM/QCS自凝胶在湿纸巾表面上表现出良好的粘合性能。此外，QCS的引入提高了自凝止血粉的抗菌活性。此外，制备的PAA/PAM/QCS粉末可以快速吸附大量血液，聚集血细胞和血小板。体内止血结果表明，PAA/PAM/QCS粉末在出血量和止血时间方面均优于对照组和市售产品组（壳聚糖粉末），其性能与止血沸石相似。因此，PAA/PAM/QCS自胶粉在快速止血方面显示出巨大的应用前景。