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Povetacicept，一种增强型双重 APRIL/BAFF 拮抗剂，可调节 B 淋巴细胞和致病性自身抗体，用于治疗狼疮和其他 B 细胞相关的自身免疫性疾病
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2023-01-27 , DOI: 10.1002/art.42462 Lawrence S Evans 1 , Katherine E Lewis 1 , Daniel DeMonte 1 , Janhavi G Bhandari 1 , Logan B Garrett 1 , Joseph L Kuijper 1 , Daniel Ardourel 1 , Martin F Wolfson 1 , Susan Debrot 1 , Sherri Mudri 1 , Kayla Kleist 1 , Luana L Griffin 1 , LuAnne Hebb 1 , Russell J Sanderson 1 , NingXin Wang 1 , Michelle Seaberg 1 , Allison G Chunyk 1 , Jing Yang 1 , Youji Hong 1 , Zahra Maria 1 , David J Messenheimer 1 , Pamela M Holland 1 , Stanford L Peng 1 , Mark W Rixon 1 , Stacey R Dillon 1
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2023-01-27 , DOI: 10.1002/art.42462 Lawrence S Evans 1 , Katherine E Lewis 1 , Daniel DeMonte 1 , Janhavi G Bhandari 1 , Logan B Garrett 1 , Joseph L Kuijper 1 , Daniel Ardourel 1 , Martin F Wolfson 1 , Susan Debrot 1 , Sherri Mudri 1 , Kayla Kleist 1 , Luana L Griffin 1 , LuAnne Hebb 1 , Russell J Sanderson 1 , NingXin Wang 1 , Michelle Seaberg 1 , Allison G Chunyk 1 , Jing Yang 1 , Youji Hong 1 , Zahra Maria 1 , David J Messenheimer 1 , Pamela M Holland 1 , Stanford L Peng 1 , Mark W Rixon 1 , Stacey R Dillon 1
Affiliation
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APRIL/BAFF 信号失调与多种自身免疫性疾病的发病机制有关，包括系统性红斑狼疮和狼疮性肾炎。我们开展这项研究是为了开发和评估高亲和力 APRIL/BAFF 拮抗剂，以克服现有 B 细胞抑制剂的临床局限性。
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更新日期：2023-01-27
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