Dynamic hydrogels have been proved valuable in tissue engineering and wound healing, but improving the functionality of these hydrogels without introducing active substances for adapting to the complex chronic wound environment is still challenging. Herein, we present an MoS₂ accelerated gelling hydrogel scaffold via in situ three-dimensional (3D) bioprinting for promoting chronic diabetic wound healing. The simple mixing of benzaldehyde and cyanoacetate group-functionalized dextran solutions with MoS₂ nanosheets would lead to the ultrafast formation of the hydrogel, which inspired us to employ the mixture as a microfluidic 3D-bioprinting ink. Besides, the printed MoS₂ hydrogel scaffold exhibited antioxidant and photothermal antibacterial properties owing to the existence of MoS₂ nanosheets. Thus, by directly printing the scaffold in the chronic diabetic wounds, we observed accelerated wound healing with promoted wound closure, alleviated oxidative stress, and eliminated bacterial infection. These indicated that the MoS₂ accelerated gelling hydrogel scaffolds are valuable for chronic wound management.

动态水凝胶已被证明在组织工程和伤口愈合中具有重要价值，但在不引入活性物质以适应复杂的慢性伤口环境的情况下改进这些水凝胶的功能仍然具有挑战性。在此，我们提出了一种通过原位三维 (3D) 生物打印促进慢性糖尿病伤口愈合的MoS ₂加速胶凝水凝胶支架。_{将苯甲醛和氰基乙酸酯基团功能化的葡聚糖溶液与 MoS 2}纳米片简单混合将导致水凝胶的超快形成，这启发我们将混合物用作微流体 3D 生物打印墨水。此外，印刷的 MoS ₂由于MoS ₂纳米片的存在，水凝胶支架表现出抗氧化和光热抗菌性能。因此，通过直接在慢性糖尿病伤口中打印支架，我们观察到伤口愈合加速，伤口闭合促进，氧化应激减轻，细菌感染消除。这些表明 MoS ₂加速凝胶化水凝胶支架对于慢性伤口处理很有价值。