Organic photoredox catalyzed dealkylation/acylation of tertiary amines to access amides,Chemical Communications

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Organic photoredox catalyzed dealkylation/acylation of tertiary amines to access amides
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-27 , DOI: 10.1039/d2cc05842a
Chen Liu ₁ , Han-Nan Chen ₁ , Teng-Fei Xiao ₁ , Xiu-Qin Hu ₁ , Peng-Fei Xu _{1,

2} , Guo-Qiang Xu ₁

Affiliation

A mild metal-free C–N bond activation strategy for the direct conversion of inert tertiary amines with acyl chlorides into tertiary amides via organic photoredox catalysis is presented. In this protocol, a novel organic photocatalyst (Cz-NI-Ph) that showed excellent catalytic performance during C–N bond cleavage is developed. Moreover, this reaction features green and mild conditions, broad substrate scope, and readily available raw materials.

中文翻译：

有机光氧化还原催化叔胺脱烷基化/酰化以获得酰胺

提出了一种温和的无金属 C-N 键活化策略，用于通过有机光氧化还原催化将惰性叔胺与酰氯直接转化为叔酰胺。在该协议中，开发了一种新型有机光催化剂 (Cz-NI-Ph)，该催化剂在 C-N 键裂解过程中表现出优异的催化性能。此外，该反应绿色温和，底物适用范围广，原料易得。

更新日期：2023-01-30

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