用于具有可调性质的水凝胶的基于核苷的交联剂,ACS Applied Materials & Interfaces

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用于具有可调性质的水凝胶的基于核苷的交联剂
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-01-26 , DOI: 10.1021/acsami.2c19525
Rafael Itzhakov _{1,

2} , Dmitry Tworowski ₃ , Noy Sadot _{2,

4} , Tali Sayas ₄ , Elazar Fallik ₁ , Maya Kleiman ₄ , Elena Poverenov ₁

Affiliation

在此，我们报告了生物衍生的交联剂，以创建具有可调特性的基于生物聚合物的水凝胶。核苷（肌苷和尿苷）和核糖（含氮碱基的戊糖）被部分氧化，产生肌苷二醛 (IdA)、尿苷二醛 (UdA) 和核糖二醛 (RdA)。二醛进一步用作多糖壳聚糖的交联剂以形成水凝胶。根据交联剂的类型和浓度，水凝胶显示出可调的流变学、机械和液体保持特性，从而可以制备可注射、柔软和可塑的水凝胶。计算模型和分子动力学模拟阐明了水凝胶的形成，并揭示了除了共价键合之外，非共价相互作用（π-π 堆积、阳离子-π、和氢键）也显着促进了交联过程。为了展示各种应用可能性，制备的水凝胶被用作植物细胞的生长平台，用作逐层 3D 打印应用的可注射墨水，以及用于软光刻复制植物微观结构的可模压水凝胶。这些发现表明，所获得的可调谐生物相容性水凝胶有可能成为各种生物技术应用的良好候选者。

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Nucleoside-Based Cross-Linkers for Hydrogels with Tunable Properties

Herein, we report bioderived cross-linkers to create biopolymer-based hydrogels with tunable properties. Nucleosides (inosine and uridine) and ribose (pentose sugar lucking the nitrogenous base) were partially oxidized to yield inosine dialdehyde (IdA), uridine dialdehyde (UdA), and ribose dialdehyde (RdA). The dialdehydes were further used as cross-linkers with polysaccharide chitosan to form hydrogels. Depending on the cross-linker type and concentration, the hydrogels showed tunable rheological, mechanical, and liquid holding properties allowing the preparation of injectable, soft, and moldable hydrogels. Computational modeling and molecular dynamics simulations shed light on hydrogel formation and revealed that, in addition to covalent bonding, noncovalent interactions (π–π stacking, cation−π, and H-bonding) also significantly contributed to the cross-linking process. To demonstrate various application possibilities, the prepared hydrogels were used as a growth platform for plant cells, as injectable inks for layer-by-layer 3D printing applications, and as moldable hydrogels for soft lithography to replicate the microstructure of the plant. These findings suggest that the obtained tunable biocompatible hydrogels have the potential to be good candidates for various biotechnological applications.

更新日期：2023-01-26

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