Tissue engineering and regenerative medicine is becoming an important component in modern biological scientific research. Tissue engineering, a branch of regenerative medicine, is a field that is actively developing to meet the challenges presented in biomedical applications. This particularly applies to the research area of stem cells and biomaterials, due to both being pivotal determinants for the successful restoration or regeneration of damaged tissues and organs. Recently, the development of innovative marine collagen-based biomaterials has attracted attention due to the reported environmentally friendly properties, the lack of zoonotic disease transmission, biocompatibility, bioactivity, the lack of ethics-related concerns and cost-effectiveness for manufacturing. The present review aimed to summarize the potential application and function of marine collagen in stem cell research in a medical and clinical setting. In addition, the present review cited recent studies regarding the latest research advances into using marine collagen for cartilage, bone, periodontal and corneal regeneration. It also characterized the distinct advantages of using marine collagen for stem cell-based tissue repair and regeneration. In addition, the present review comprehensively discussed the most up to date information on stem cell biology, particularly the possibility of treating stem cells with marine collagen to maximize their multi-directional differentiation capability, which highlights the potential use of marine collagen in regenerative medicine. Furthermore, recent research progress on the potential immunomodulatory capacity of mesenchymal stem cells following treatment with marine collagen to improve the understanding of cell-matrix interactions was investigated. Finally, perspectives on the possible future research directions for the application of marine collagen in the area of regenerative medicine are provided.

中文翻译：

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海洋胶原蛋白在干细胞疗法和组织再生中的应用（综述）。

组织工程与再生医学正成为现代生物科学研究的重要组成部分。组织工程是再生医学的一个分支，是一个正在积极发展以应对生物医学应用中提出的挑战的领域。这尤其适用于干细胞和生物材料的研究领域，因为它们都是受损组织和器官成功修复或再生的关键决定因素。最近，由于报道的环境友好特性、缺乏人畜共患疾病传播、生物相容性、生物活性、缺乏伦理相关问题和制造成本效益，创新的海洋胶原基生物材料的开发引起了人们的关注。本综述旨在总结海洋胶原蛋白在医学和临床环境中干细胞研究中的潜在应用和功能。此外，本综述引用了最近关于使用海洋胶原蛋白进行软骨、骨骼、牙周和角膜再生的最新研究进展的研究。它还表征了使用海洋胶原蛋白进行基于干细胞的组织修复和再生的独特优势。此外，本综述全面讨论了干细胞生物学的最新信息，特别是用海洋胶原蛋白处理干细胞以最大化其多向分化能力的可能性，突出了海洋胶原蛋白在再生医学中的潜在用途。此外，研究了用海洋胶原蛋白处理后间充质干细胞潜在免疫调节能力的最新研究进展，以提高对细胞-基质相互作用的理解。最后，对海洋胶原蛋白在再生医学领域的应用未来可能的研究方向进行了展望。