Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation,Angewandte Chemie International Edition

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Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-01-26 , DOI: 10.1002/anie.202214935
Yijiao Qu ₁ , Robert De Rose ₁ , Chan-Jin Kim ₁ , Jiajing Zhou ₁ , Zhixing Lin ₁ , Yi Ju ₁ , Sukhvir Kaur Bhangu _{1,

2} , Christina Cortez-Jugo ₁ , Francesca Cavalieri _{2,

3} , Frank Caruso ₁

Affiliation

DNA-based particles with various morphologies and functions are fabricated via the supramolecular assembly of tannic acid (TA) and DNA. The engineered particles enable in vivo co-delivery of adjuvant/antigen to boost cytokine and antibody production.

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