Construction of Functionalized 2H-Pyran-2-ones via N-Heterocyclic Carbene-Catalyzed [3 + 3] Annulation of Alkynyl Esters with Enolizable Ketones,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Construction of Functionalized 2H-Pyran-2-ones via N-Heterocyclic Carbene-Catalyzed [3 + 3] Annulation of Alkynyl Esters with Enolizable Ketones
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-01-25 , DOI: 10.1021/acs.joc.2c02392
Zheng Liang ₁ , Jibin Li ₁ , Lei Wang ₁ , Zexuan Wei ₁ , Jiahui Huang ₁ , Xinrui Wang ₁ , Ding Du ₁

Affiliation

A new synthesis of functionalized 2H-pyran-2-ones has been developed through N-heterocyclic carbene-catalyzed formal [3 + 3] annulation of alkynyl esters with enolizable ketones. The key to the success of this protocol relies on the use of an NHC instead of a tertiary amine as the catalyst. This protocol also features a broad substrate scope and mild metal-free conditions, offering simple and rapid access to the target molecules in a highly regioselective manner.

中文翻译：

N-杂环卡宾催化 [3 + 3] 炔基酯与烯醇化酮成环反应构建功能化 2H-吡喃-2-酮

通过 N-杂环卡宾催化的炔基酯与可烯醇化酮的正式 [3 + 3] 环化，开发了功能化 2 H -pyran-2-ones的新合成方法。该协议成功的关键在于使用 NHC 而不是叔胺作为催化剂。该协议还具有广泛的底物范围和温和的无金属条件，以高度区域选择性的方式提供对目标分子的简单快速访问。

更新日期：2023-01-25

点击分享查看原文

点击收藏

阅读更多本刊新发论文