The discovery of natural adhesion phenomena and mechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.

近几十年来，自然粘附现象和机制的发现推动了新一代组织粘合剂的开发。在这项研究中，我们从蜗牛粘液凝胶中开发出一种天然生物粘合剂，它由带正电荷的蛋白质和聚阴离子糖胺聚糖网络组成。可延展的块状粘合剂基质可以通过多重相互作用粘附到湿纸巾上。该生物材料表现出优异的止血活性、生物相容性和生物降解性，可有效加速正常和糖尿病雄性大鼠全层皮肤伤口的愈合。进一步的机理研究表明，它有效促进巨噬细胞向抗炎表型的极化，减轻慢性伤口的炎症，并显着改善上皮再生和血管生成。其丰富的类肝素糖胺聚糖成分是主要活性成分。这些发现为仿生组织粘合剂和生物工程支架设计提供了理论和材料见解。