A copper catalyzed controllable α-chlorination of nafimidone derivatives with HCl was achieved. This green and efficient catalysis proceeds via a ligand to metal charge transfer (LMCT) process and used air as a green oxidant. With different reaction conditions, the chlorinated or dichlorinated nafimidone derivatives could be controllable synthesized in good to excellent yields with a high functional group tolerance and a broad substrate scope. This controllable and practical strategy provides access to potentially bioactive nafimidone derivatives.

中文翻译：

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通过 CuCl2 的 LMCT 激发可见光诱导萘菲咪酮衍生物的可控 α-氯化

实现了铜催化萘咪酮衍生物与盐酸的可控α-氯化反应。这种绿色高效的催化作用通过配体到金属电荷转移 (LMCT) 过程进行，并使用空气作为绿色氧化剂。在不同的反应条件下，氯化或二氯化萘咪酮衍生物可以以良好的产率可控合成，具有高官能团耐受性和广泛的底物范围。这种可控且实用的策略提供了获得具有潜在生物活性的萘咪酮衍生物的途径。