Metal/reducible metal oxide catalysts are widely used in hydrodeoxygenation (HDO) reactions for upgrading bio-oil to produce chemicals and fuel components. Under such strong reducing condition, the strong metal-support interaction (SMSI) should take place, however, few work has been devoted to understand the effect of facet of metal oxide on the SMSI and its consequence on HDO performance. Herein, Pt supported on anatase TiO₂ with varying dominative exposed facets of (1 0 1), (1 0 0) and (0 0 1) were prepared and tested in HDO of m-cresol at 350 °C and atmosphere H₂ pressure. The degree of SMSI of Pt/TiO₂ is strongly dependent on the facet of TiO₂ when reduced at 350 °C, and the degree of encapsulation decreases following the order of Pt/TiO₂-100 > Pt/TiO₂-001 > Pt/TiO₂-101. The encapsulation correlates well with the reduction degree of TiO₂ and the location of oxygen vacancy, which are resulted from varied oxygen vacancy formation and anisotropic diffusion rates in different facets. The intermediate SMSI is achieved on TiO₂-001, which creates the maximal density of Pt-O_v-Ti³⁺ sites at the interfacial perimeter of TiO_x/Pt for deoxygenation of m-cresol, resulting in the highest reaction rate and turnover frequency (TOF) while the lowest activation energy (E_a). In contrast, the maximum SMSI on TiO₂-100 leads to the lowest deoxygenation rate while the highest E_a. This work provides insight into facet dependent SMSI of Pt/TiO₂ and indicates the HDO activity can be finely tailored by tuning the facet of TiO₂.