The existing QuEChERS-combined analytical pretreatment methods are limited by large reagent consumption, high environmental burden, and mediocre effects. To provide an efficient and green pretreatment method, this study developed pH-responsive switchable deep eutectic solvents (SDESs) to extract triazole fungicides (TFs) from fruit peel wastes, which could enhance the preconcentration effect of target compounds in food waste samples with complex matrices. The mechanisms of pH-induced phase transition and hydrophobicity-hydrophilicity conversion of pH-responsive SDESs were investigated by pH phase diagrams and chemical characterization techniques, respectively. We validated the established method by high-performance liquid chromatography-diode array detector (HPLC-DAD), and lower LOD (0.089–0.351 ng mL⁻¹), LOQ (0.297–1.172 ng mL⁻¹), RSD (≤8.8 %) and satisfactory recoveries (90.6 %-110.9 %) and preconcentration factors (389–512) were obtained in rotting grape peel, watermelon peel, and orange peel samples. Our findings highlight the potential of pH-responsive SDESs in the extraction and analysis of various natural food products.

现有的QuEChERS联合分析前处理方法存在试剂消耗大、环境负担高、效果一般等问题。为了提供一种高效、绿色的预处理方法，本研究开发了 pH 响应型可切换低共熔溶剂 (SDESs)，用于从果皮废弃物中提取三唑类杀菌剂 (TFs)，从而增强目标化合物在复杂基质食品废弃物样品中的预富集效果. 通过 pH 相图和化学表征技术分别研究了 pH 响应性 SDES 的 pH 诱导相变和疏水性-亲水性转化机制。我们通过高效液相色谱-二极管阵列检测器 (HPLC-DAD) 和较低的 LOD (0.089–0.351 ng mL ^-1), LOQ (0.297–1.172 ng mL ^-1 ), RSD (≤8.8 %) 和令人满意的回收率 (90.6 %-110.9 %) 和富集因子 (389–512) 在腐烂的葡萄皮、西瓜皮和橙皮中获得样品。我们的研究结果突出了 pH 响应性 SDES 在各种天然食品的提取和分析中的潜力。