<br>UFMylation 指南，一种新兴的翻译后修饰,The FEBS Journal

当前位置： X-MOL 学术 › FEBS J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

UFMylation 指南，一种新兴的翻译后修饰
The FEBS Journal ( IF 5.5 ) Pub Date : 2023-01-20 , DOI: 10.1111/febs.16730
David Millrine ₁ , Joshua J Peter ₁ , Yogesh Kulathu ₁

Affiliation

泛素折叠修饰剂-1 (UFM1) 是一种类泛素修饰剂 (UBL)，通过大多数真核生物中保守的专用酶系统在翻译后附着于底物上的赖氨酸残基。尽管 UFM1 和泛素之间结构相似，但 UFMylation 机制采用独特的机制来确保保真度。虽然 UFMylation 的生理触发因素和后果尚不完全清楚，但其生物学重要性体现在人类病理生理学（包括肌肉骨骼和神经发育疾病）中 UFMylation 途径的突变。其中一些疾病可以通过在 UFMylation 丧失时观察到的内质网 (ER) 应激增加和翻译稳态破坏来解释。 UFM1 在这些过程中的作用可能源于其在 ER 中的功能，其中核糖体因翻译停滞而被 UFM1 化。此外，UFMylation 还涉及其他细胞过程，包括 DNA 损伤反应和端粒维持。因此，对 UFM1 通路机制及其生物学功能的研究将揭示对基础细胞生物学的见解，并可能为造福人类健康提供新的治疗机会。为此，我们在此提供了有关 UFM1 生物发生、结合和功能的当前知识状态的全面指南，重点是潜在机制。

"点击查看英文标题和摘要"

A guide to UFMylation, an emerging posttranslational modification

Ubiquitin Fold Modifier-1 (UFM1) is a ubiquitin-like modifier (UBL) that is posttranslationally attached to lysine residues on substrates via a dedicated system of enzymes conserved in most eukaryotes. Despite the structural similarity between UFM1 and ubiquitin, the UFMylation machinery employs unique mechanisms that ensure fidelity. While physiological triggers and consequences of UFMylation are not entirely clear, its biological importance is epitomized by mutations in the UFMylation pathway in human pathophysiology including musculoskeletal and neurodevelopmental diseases. Some of these diseases can be explained by the increased endoplasmic reticulum (ER) stress and disrupted translational homeostasis observed upon loss of UFMylation. The roles of UFM1 in these processes likely stem from its function at the ER where ribosomes are UFMylated in response to translational stalling. In addition, UFMylation has been implicated in other cellular processes including DNA damage response and telomere maintenance. Hence, the study of UFM1 pathway mechanics and its biological function will reveal insights into fundamental cell biology and is likely to afford new therapeutic opportunities for the benefit of human health. To this end, we herein provide a comprehensive guide to the current state of knowledge of UFM1 biogenesis, conjugation, and function with an emphasis on the underlying mechanisms.

更新日期：2023-01-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文