It is now well recognized that a bidirectional relationship between gut microbiota and the brain, referred to as the gut-brain axis, plays a prominent role in maintaining homeostasis and that a disruption in this axis can result in neuroinflammatory response and neurological disorders such as Parkinson’s disease (PD). The protective action of probiotics such as Bifidobacterium animalis ssp. lactis Bb12 and Lactobacillus rhamnosus GG in various animal models of PD has been reported. Therefore, in this study, we used an inflammatory model of PD to assess the effects of a combination of these two probiotics (Microbiot^®) on motor behavior as well as on the response of microglia, including microglia morphology, to gain a better understanding of their mechanism of action. Microbiot^® (300 µL) was administered orally once daily for 15 days in a lipopolysaccharide-induced PD model using male Wistar rats. Although LPS-induced motor asymmetry in cylinder test was not affected by Microbiot^®, impairment of motor coordination in the narrow-beam test was significantly reduced by this probiotic. Moreover, Microbiot^® treatment reduced microglial activation suggesting an anti-inflammatory effect. While further mechanistic investigation of Microbiot^® in neurodegenerative diseases is warranted, our results support the potential utility of probiotics in PD.

现在公认的是，肠道微生物群与大脑之间的双向关系，称为肠-脑轴，在维持体内平衡方面起着重要作用，并且该轴的破坏会导致神经炎症反应和神经系统疾病，例如帕金森病疾病（PD）。动物双歧杆菌等益生菌的保护作用。已报道各种 PD 动物模型中的乳杆菌 Bb12和鼠李糖乳杆菌 GG 。^{因此，在这项研究中，我们使用 PD 的炎症模型来评估这两种益生菌（Microbiot® ）}组合的效果) 对运动行为以及小胶质细胞的反应，包括小胶质细胞形态，以更好地了解它们的作用机制。在使用雄性 Wistar 大鼠的脂多糖诱导的 PD 模型中，每天一次口服Microbiot ^{® (300 µL)，持续 15 天。}虽然 LPS 在气缸测试中引起的运动不对称不受 Microbiot ^®的影响，但这种益生菌显着减少了窄束测试中运动协调的损害。此外，Microbiot ^®治疗减少了小胶质细胞的激活，表明具有抗炎作用。虽然对 Microbiot ^®在神经退行性疾病中的进一步机制研究是必要的，但我们的结果支持益生菌在 PD 中的潜在用途。