脱细胞细胞外基质水凝胶治疗椎间盘退变的研究进展,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

脱细胞细胞外基质水凝胶治疗椎间盘退变的研究进展
Biomaterials Science ( IF 5.8 ) Pub Date : 2023-01-20 , DOI: 10.1039/d2bm01862d
Bing Peng ₁ , Lilong Du ₂ , Tongxing Zhang ₂ , Jiangping Chen ₃ , Baoshan Xu ₂

Affiliation

作为最常见的临床疾病之一，腰痛 (LBP) 影响患者的生活质量，并造成巨大的社会和经济负担。许多因素可导致 LBP，其中最常见的是椎间盘退变 (IDD)。IDD的进展不能通过保守或手术治疗来缓解，基因治疗、生长因子治疗和细胞治疗都有其局限性。近年来，利用水凝胶生物材料治疗IDD的研究引起了人们的极大兴趣，并取得了令人满意的治疗效果。本文介绍了水凝胶的分类、脱细胞细胞外基质 (dECM) 的生产方法和各种类型的凝胶形成。本文详细介绍了目前关于 dECM 水凝胶治疗 IDD 的研究。首先，概述了材料来源、脱细胞方法和凝胶形成方法。重点是过去三年进行的研究，主要由牛和猪的 NP 组织组成，而对于脱细胞方法，主要使用几种方法的组合。dECM 水凝胶在聚合物交联后具有显着改善的机械性能。这些凝胶的主要作用包括诱导干细胞分化为椎间盘 (IVD) 细胞、良好的机械性能以在聚合物交联后恢复 IVD 高度，以及外泌体的缓慢释放。最后，总结了 dECM 水凝胶在治疗 IDD 方面仍面临的挑战和问题，并提出了可能的解决方案。

"点击查看英文标题和摘要"

Research progress in decellularized extracellular matrix hydrogels for intervertebral disc degeneration

As one of the most common clinical disorders, low back pain (LBP) influences patient quality of life and causes substantial social and economic burdens. Many factors can result in LBP, the most common of which is intervertebral disc degeneration (IDD). The progression of IDD cannot be alleviated by conservative or surgical treatments, and gene therapy, growth factor therapy, and cell therapy have their own limitations. Recently, research on the use of hydrogel biomaterials for the treatment of IDD has garnered great interest, and satisfactory treatment results have been achieved. This article describes the classification of hydrogels, the methods of decellularized extracellular matrix (dECM) production and the various types of gel formation. The current research on dECM hydrogels for the treatment of IDD is described in detail in this article. First, an overview of the material sources, decellularization methods, and gel formation methods is given. The focus is on research performed over the last three years, which mainly consists of bovine and porcine NP tissues, while for decellularization methods, combinations of several approaches are primarily used. dECM hydrogels have significantly improved mechanical properties after the polymers are cross-linked. The main effects of these gels include induction of stem cell differentiation to intervertebral disc (IVD) cells, good mechanical properties to restore IVD height after polymer cross-linking, and slow release of exosomes. Finally, the challenges and problems still faced by dECM hydrogels for the treatment of IDD are summarised, and potential solutions are proposed. This paper is the first to summarise the research on dECM hydrogels for the treatment of IDD and aims to provide a theoretical reference for subsequent studies.

更新日期：2023-01-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南