Fluorescent molecules confined into the nanopores of metal-organic frameworks generally display alterant luminescence properties, which exhibits broad application prospects. Herein, trans-4-[4-(N,N′-dimethylamino)styryl]pyridine (DMSP) was confined in the nanocavities of UiO-66, and the concomitant fluorescence color change made this host-guest material capable to act as a drug carrier that monitored drug release with luminescence. DMSP radiated green fluorescence with excitation and emission wavelengths at 381 and 478 nm, respectively. While after DMSP was confined in UiO-66, the excitation and emission wavelengths respectively red-shifted to 528 and 579 nm, accompanied by orange fluorescence emission. This luminescence color transformation was confirmed to be associated with the interaction of pyridine N-atom in DMSP with Bronsted acid sites in UiO-66, enhancing the electron push-pull effect of DMSP. This host-guest material remained the biocompatibility, porosity and degradability of UiO-66, and moreover the fluorescence color transformation from orange to green occurred after its decomposition by PO₄³⁻. On this basis, this host-guest material was capable to serve as a drug carrier that monitored drug release with the fluorescence signal, which facilitated the visual tracking of drug release in vivo.

限制在金属有机骨架纳米孔中的荧光分子通常表现出可变的发光特性，具有广阔的应用前景。在此，反式-4-[4-(N,N'-二甲基氨基)苯乙烯基]吡啶 (DMSP) 被限制在 UiO-66 的纳米腔中，伴随的荧光颜色变化使这种主客体材料能够充当用发光监测药物释放的药物载体。DMSP 辐射绿色荧光，激发和发射波长分别为 381 和 478 nm。而将 DMSP 限制在 UiO-66 中后，激发和发射波长分别红移至 528 和 579 nm，并伴有橙色荧光发射。这种发光颜色的转变被证实与吡啶的相互作用有关。DMSP 中的N原子与 UiO-66 中的 Bronsted 酸位点，增强了 DMSP 的电子推拉效应。_{这种主客体材料保持了UiO-66的生物相容性、孔隙率和可降解性，而且在被PO 4} ³⁻分解后荧光颜色由橙色变为绿色。在此基础上，该主客体材料可作为药物载体，通过荧光信号监测药物释放，实现体内药物释放的可视化追踪。