Iron-Catalyzed Synthesis of Benzosultams from N-Phenyl-N-(prop-2-yn-1-yl)benzenesulfonamide and Benzenesulfonyl Hydrazine,Organic Letters

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Iron-Catalyzed Synthesis of Benzosultams from N-Phenyl-N-(prop-2-yn-1-yl)benzenesulfonamide and Benzenesulfonyl Hydrazine
Organic Letters ( IF 4.9 ) Pub Date : 2023-01-19 , DOI: 10.1021/acs.orglett.2c04134
Mei Zhang ₁ , Xiao Yu ₁ , Wenjing Zhu ₁ , Yi Liu ₁ , Zenghui Zhang ₁ , Jinbo Zhao ₁ , Chengcai Xia ₁ , Ke Li ₁

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A novel route for an iron-catalyzed tandem sulfonylation, C(sp²)–H activation, cyclization reaction which uses N-phenyl-N-(prop-2-yn-1-yl)benzenesulfonamide and benzenesulfonohydrazide to synthesize derivatives of (Z)-2-phenyl-4-((phenylsulfonyl)methylene)-3,4-dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxide has been developed. The method features convenient operation and good functional group tolerance. In addition, it employs insensitive and inexpensive FeSO₄ as the catalyst and provides a direct approach for the preparation of benzothiazides.

中文翻译：

N-苯基-N-(prop-2-yn-1-yl)苯磺酰胺和苯磺酰肼铁催化合成苯磺胺

N-苯基-N- (prop-2-yn-1-yl)苯磺酰胺和苯磺酰肼铁催化串联磺酰化C(sp ² )-H活化环化反应合成( Z )-2-phenyl-4-((phenylsulfonyl)methylene)-3,4-dihydro-2 H -benzo[ e ][1,2]thiazine 1,1-dioxide 已经开发出来。该方法操作方便，官能团耐受性好。此外，它采用不敏感且廉价的FeSO ₄作为催化剂，为制备苯并噻嗪提供了一种直接的途径。

更新日期：2023-01-19

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