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(+)/(−)-Alexanoid A, a pair of enantiomeric sesquiterpenoid with a novel 5/6/6 tricyclic backbone from the stem of Syringa pinnatifolia
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2023-01-18 , DOI: 10.1016/j.tetlet.2023.154372 Changxin Liu , Panlong Chen , Shungang Jiao , Hongying Chen , Jixuan Xu , Xiaoli Gao , Xingyun Chai
中文翻译:
(+)/(−)-Alexanoid A,一对具有新型 5/6/6 三环主链的对映体倍半萜,来自丁香叶丁香的茎
更新日期:2023-01-18
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2023-01-18 , DOI: 10.1016/j.tetlet.2023.154372 Changxin Liu , Panlong Chen , Shungang Jiao , Hongying Chen , Jixuan Xu , Xiaoli Gao , Xingyun Chai
A pair of enantiomeric sesquiterpenoid, namely (+)/(−)-alexanoid A (1a and 1b), with an unprecedented 4,11,11-trimethyltricyclo[6.3.1.01,5] dodecane skeleton (proposed alexane), was discovered from the peeled stems of Syringa pinnatifolia Hemsl. The structures were elucidated by the spectroscopic data analysis including NMR, UV, IR, optical rotation (OR), and electronic circular dichroism (ECD) calculation, and the protective activity on H9c2 cardiomyocytes and anti-inflammatory activity against NO production in lipopolysaccharide (LPS)-induced RAW264.7 cells were evaluated.
中文翻译:
(+)/(−)-Alexanoid A,一对具有新型 5/6/6 三环主链的对映体倍半萜,来自丁香叶丁香的茎
从_ _ _ _紫丁香去皮的茎。通过包括 NMR、UV、IR、旋光度 (OR) 和电子圆二色性 (ECD) 计算在内的光谱数据分析阐明了结构,以及对 H9c2 心肌细胞的保护活性和对脂多糖 (LPS) 中 NO 产生的抗炎活性) 诱导的 RAW264.7 细胞进行了评估。